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Theme 2: Modes of toxicity

Theme 2: Introduction

The concept of a mode of toxicity is an understanding of the interaction of a chemical with cellular biochemistry from the level of exposure though to outcome, and therefore includes internal exposure, mechanisms of toxicity and disease pathways. With the exception of disease pathways these aspects... Read more...

Theme 2: Project 1 - Early life exposures and effect

The foetus represents one of the most vulnerable stages of life for susceptibility to the effects of chemical exposure. This has been highlighted in several publications and remains of public concern as demonstrated by the interest that surrounded the publication in 2013 of a report from the... Read more...

Theme 2: Project 2 - Toxicokinetics

The majority of epidemiological studies are carried out using an assessment of external/blood or urine exposure measures. These are most often though not the target organ or cell of interest that is usually not available for analysis. To overcome this deficiency modelling approaches are used to... Read more...

Theme 2: Project 3 - Environmental and Human Microbiome

Exposure to environmental microbiomes occurs though bioaerosols. This project focusses particularly on the application of molecular methods to the analysis of fungal species in molecular epidemiology.  It links both with Theme I and also to the bioaerosol work in the Environmental Change and... Read more...

Theme 2: Project 4 - Genotoxicity of air pollutants

Air pollution is carcinogenic. Genotoxic components of polluted air can interact with cellular macromolecules to form adducts. High resolution mass spectrometry affords the opportunity to conduct global analyses of DNA and protein adducts (adductomics) to determine the normal variation in both... Read more...

Theme 2: Project 5 - Approaches to analysis of the serum and urinary metabolome

As part of our work on the exposome, we will investigate a series of analytic approaches for the analysis of the human metabolome, using data derived from the EU FP7 Combi-Bio project and the AIRWAVE study (Theme 3). Combi-Bio is providing a rich dataset on the serum metabolome from the... Read more...