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Theme 2: Modes of toxicity (Biochemical pathways from toxin to disease)

Theme 2: Introduction

The concept of a mode of toxicity is an understanding of the interaction of a chemical with cellular biochemistry from the level of exposure though to outcome, and therefore includes internal exposure, mechanisms of toxicity and disease pathways. With the exception of disease pathways these aspects... Read more...

Theme 2: Project 1 - Early life exposures and effect

The foetus represents one of the most vulnerable stages of life for susceptibility to the effects of chemical exposure. This has been highlighted in several publications and remains of public concern as demonstrated by the interest that surrounded the publication in 2013 of a report from the... Read more...

Theme 2: Project 3 - Environmental and Human Microbiome

Exposure to environmental microbiomes occurs though bioaerosols. This project focusses particularly on the application of molecular methods to the analysis of fungal species in molecular epidemiology.  It links both with Theme I and also to the bioaerosol work in the Environmental Change and... Read more...

Theme 2: Project 5 - Analysis of the serum and urinary metabolome in relation to air pollutants

As part of our work on the exposome, and linking to Theme IV, we are investigating the serum and urinary human metabolome in relation to air pollution.

We are using various short-term exposure chamber studies and a population cohort, the US MESA study which has a rich dataset on the serum... Read more...

Theme 2: Project 6 - UVCB Grouping

One of the most challenging areas in regulatory toxicology is assessment of the UVCBs (Unknown or Variable composition, Complex reaction products and Biological materials). UVCBs are substances with few solutions for science-informed regulatory decisions. Regulators and registrants have a common... Read more...

Theme 2: Project 7 – E-cigarette risk

E-cigarettes first appeared in the UK as an import from China in 2006. These were relatively low power and now called first generation devices. Since that time battery and other technological developments have led to the second and third generation devices that are more controllable, have higher... Read more...