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Theme 2: Project 5 - Analysis of the serum and urinary metabolome in relation to air pollutants
As part of our work on the exposome, and linking to Theme IV, we are investigating the serum and urinary human metabolome in relation to air pollution.
We are using various short-term exposure chamber studies and a population cohort, the US MESA study which has a rich dataset on the serum metabolome from untargeted analysis of 4,000 samples using both Nuclear Magnetic Resonance (NMR) and Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS).
Air pollution exposures based at place of residence are already available from the MESA study. We aim to discover potential markers of air pollutants in MESA and investigate to what extent these are related to cardiovascular risk factors and inflammatory markers in MESA-Air. A MRC project grant has been submitted to accommodate this research