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Dr Tim Marczylo



Theme 2 - Modes of toxicity (Biochemical pathways from toxin to disease)

Public Health England

Principal Toxicology, Toxicology Department/General Toxicology, PHE.

Honorary Lecturer, King’s College London

Tim is a Principal Toxicologist in the Toxicology Department at the Centre for Radiation, Chemical and Environmental Hazards, PHE, UK, visiting senior lecturer, Kings College London and visiting lecturer at University of Leicester. 

He received his undergraduate (Biochemistry) degree from University of Surrey which incorporated an Industrial Professional training year spent at MAFF (later CSL, now FERA) working on the metabolism and pharmacokinetics of second generation anticoagulant rodenticides. Tim stayed on at Surrey to complete a Wellcome Trust funded PhD in the mutagenicity and bioactivation of aromatic and heterocyclic amines under the tutelage of Prof. Costas Ioannides. 

After a brief period at MAFF, Tim took up his first post-doc at the Universita Degli Studi Di Torino with Prof Francesco DeMatteis looking at haem interactions of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) following sub-chronic oral doses in rats. 

His second Post-doc was at the Dept of Pharmaceutical Sciences, Okayama University, Japan working with Prof. Hikoya Hayatsu on the antimutagenicity of constituents of the Japanese diet in a JSPS-funded 2- year fellowship.  In 2000 Tim took up his final post-doc at the University of Wales, Aberystwyth working with Prof Steven Kelly on mechanistic investigations of the activity of CYP51 proteins obtained by heterologous expression following site-mutagenesis of C. albicans cyp51 gene to clinically relevant mutants. 

Tim took up a lectureship in Pharmacokinetics in the Dept of Cancer Studies and Molecular Medicine, University of Leicester in 2002.  In 2008 he moved floors to join the Reproductive Sciences Section and ROS Group working on projects related to endocannabinoids and 8-oxo-dG.  Whilst at Leicester Tim taught on the MBChB, and MSc in Molecular Pathology and Toxicology Course and was course co-convenor for 2 years prior to his departure.

Tim joined the toxicology department of PHE in March 2012. His scientific interests centre on analytical chemistry, predominantly LC-MS techniques, toxicokinetics, DNA adducts and human biomonitoring.

Tim currently has 70+ peer-reviewed publications either published or in print.